![]() You may see printed warnings and precautions based on these kinds of studies, but the warnings do not apply to typical or customary amounts of grapefruit of GFJ. An important point is that some of the research studies involving GFJ and statins used unrealistically large quantities of GFJ, or ‘super-strength’ forms of GFJ. These include: atorvastatin (Lipitor), lovastatin (Mevacor), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), and rosuvastatin (Crestor). All other statin derivatives are not meaningfully affected by typical quantities of grapefruit or GFJ. The GFJ-simvastatin combination is best avoided, and another statin used in its place. The only statin medication that is meaningfully affected by an interaction with customary amounts of grapefruit juice (GFJ) is simvastatin. The result is that medications ordinarily metabolized by intestinal CYP3A may end up with greater absorption and higher levels in blood, as if a higher dose were taken. Crestor side effects include pain and headaches as well as more serious complications. Crestor, or rosuvastatin, can lower cholesterol and triglyceride levels. Here is how three people describe the side effects of taking Rosuvastatin. The grapefruit itself, and juice made from the fruit, contain natural substances called furanocoumarins, which have the effect of inactivating CYP3A in the intestinal wall. Rosuvastatin, sold as Crestor, is a statin medication that lowers bad cholesterol. ![]() Greenblatt, MD, answers: “With the exception of simvastatin (Zocor), it is safe to take statin medications with customary amounts of grapefruit products – such as one glass of typical commercially-available grapefruit juice, or one-half of a whole grapefruit.Ī number of medications, including some statins, are metabolized (broken down) by an enzyme in the wall of the intestines, termed Cytochrome P450-3A, often abbreviated CYP3A.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |